Investigating how cell cycle variations affect development and disease
Official title: Cell cycle and checkpoint variations in development and disease
Funded at Trustees of Indiana University · NIH-11132606 · Data updated 2026-11-12
This study is looking at how cells grow and stay healthy using fruit flies, with the hope of finding new ways to help people with cancer by understanding why some cancer cells are tough to treat.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | July 5, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $395,926 |
| NIH project number | 5R35GM152255-02 |
| Project ID | NIH-11132606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by cancer or those interested in the biological mechanisms of cancer development.
✕Less likely to help
Patients with conditions unrelated to cancer or those not affected by cell cycle variations may not benefit from this research.
What this research studies
This research focuses on understanding the regulation of the cell cycle and genome integrity using fruit flies as a model system. The team studies different cell cycle variations, particularly a process called the endocycle, which allows cells to grow larger without dividing. By examining how these variations relate to diseases, including cancer, the research aims to uncover mechanisms that could lead to better cancer therapies. Patients may benefit from insights into how cancer cells resist treatment and how to improve therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by understanding how certain cell cycles contribute to therapy resistance.
How similar studies have gone: Other research has shown promise in understanding cell cycle variations and their implications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Calvi, Brian R — Trustees of Indiana University
- Study coordinator: Calvi, Brian R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.