Investigating how cell cycle variations affect development and disease
Cell cycle and checkpoint variations in development and disease
This study is looking at how cells grow and stay healthy using fruit flies, with the hope of finding new ways to help people with cancer by understanding why some cancer cells are tough to treat.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project ID | NIH-11132606 on NIH RePORTER |
What this research studies
This research focuses on understanding the regulation of the cell cycle and genome integrity using fruit flies as a model system. The team studies different cell cycle variations, particularly a process called the endocycle, which allows cells to grow larger without dividing. By examining how these variations relate to diseases, including cancer, the research aims to uncover mechanisms that could lead to better cancer therapies. Patients may benefit from insights into how cancer cells resist treatment and how to improve therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by cancer or those interested in the biological mechanisms of cancer development.
Not a fit: Patients with conditions unrelated to cancer or those not affected by cell cycle variations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by understanding how certain cell cycles contribute to therapy resistance.
How similar studies have performed: Other research has shown promise in understanding cell cycle variations and their implications in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Bloomington, United States
- Trustees of Indiana University — Bloomington, United States (Active)
Researchers
- Principal investigator: Calvi, Brian R — Trustees of Indiana University
- Study coordinator: Calvi, Brian R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.