Investigating how CD45 affects blood vessel changes in heart disease
CD45-mediated endothelial-to-mesenchymal transition in cardiovascular disease
This study is looking at how a protein called CD45 affects the way certain cells in your blood vessels change and contribute to heart disease, with the goal of finding new ways to help treat people with cardiovascular issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10542835 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein called CD45 in the development of atherosclerosis, a condition that leads to heart disease and stroke. The researchers aim to explore how CD45 influences the transition of endothelial cells, which line blood vessels, into a different cell type that contributes to the progression of atherosclerosis. By studying this process, they hope to identify new molecular markers and therapeutic targets that could improve treatment options for patients with cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerosis or other cardiovascular diseases.
Not a fit: Patients with non-cardiovascular conditions or those not at risk for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or slow down the progression of atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding endothelial cell behavior in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Hong — Boston Children's Hospital
- Study coordinator: Chen, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.