Investigating how Candida albicans infects the brain
Systematic Genetic Analysis of C. albicans CNS Infection
['FUNDING_R21'] · UNIVERSITY OF IOWA · NIH-10766813
This study is looking at how a common fungus called Candida albicans can infect the brain in people with weakened immune systems, like premature babies and certain adults, to find ways to prevent and treat these infections better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-10766813 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the fungus Candida albicans can infect the central nervous system (CNS), particularly in patients with weakened immune systems. The study will utilize a new model to explore the genetic factors that allow C. albicans to invade the brain, especially in vulnerable populations such as premature infants and adults with specific genetic mutations. By screening various genetic mutants, the research aims to identify key regulators involved in this infection process, which could lead to better prevention and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include premature infants and adults with mutations in the CARD9 immune pathway who are at high risk for C. albicans CNS infections.
Not a fit: Patients without a history of Candida infections or those with intact immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and outcomes for patients suffering from CNS infections caused by Candida albicans.
How similar studies have performed: While there has been significant research on fungal infections, this specific approach to understanding C. albicans neurotropism is relatively novel and has not been extensively tested.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRYSAN, DAMIAN J — UNIVERSITY OF IOWA
- Study coordinator: KRYSAN, DAMIAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections