Investigating how cancer cells resist treatment and spread in the body
Official title: Tumor-cell intrinsic and extrinsic determinants of drug resistance and metastasis
Funded at University of Nebraska Medical Center · NIH-10990396 · Data updated 2026-11-12
This study is looking into why some colorectal cancer cells don't respond to treatment and how they can spread, focusing on a protein called Claudin-1, to help find new ways to fight the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $38,693 |
| NIH project number | 1F99CA294241-01 |
| Project ID | NIH-10990396 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with advanced colorectal cancer.
✕Less likely to help
Patients with early-stage cancer or those whose cancer is not colorectal may not benefit from this research.
What this research studies
This research explores the mechanisms behind why some cancer cells become resistant to treatment and how they spread to other parts of the body. It focuses on both internal factors within the cancer cells, such as genetic changes, and external influences from the surrounding immune environment. The study will analyze the role of a specific protein, Claudin-1, in promoting resistance and metastasis in colorectal cancer, using patient samples to compare normal and cancerous tissues. By understanding these processes, the research aims to identify new targets for therapy.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with advanced cancer, potentially reducing metastasis and enhancing the effectiveness of therapies.
How similar studies have gone: Previous research has shown success in targeting similar mechanisms of drug resistance and metastasis in cancer, indicating a promising avenue for further exploration.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Primeaux, Mark — University of Nebraska Medical Center
- Study coordinator: Primeaux, Mark
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.