Investigating how calcium channels affect cognitive functions in the brain.
The role of CaV3.1 T-type calcium channels in cognitive functions mediated by the subicular circuitry
This study is looking at how certain calcium channels in a part of the brain called the subiculum affect memory and thinking, with the hope of finding new ways to help people with cognitive issues related to mental health conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10671065 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of CaV3.1 T-type calcium channels in the subiculum, a key area of the brain involved in memory and cognition. By examining how these channels influence neuronal activity and synaptic plasticity, the study aims to uncover mechanisms that could lead to new treatments for cognitive deficits associated with psychiatric disorders. The approach includes advanced techniques such as electrophysiology to analyze neuronal firing patterns and their implications for cognitive functions. Patients may benefit from insights gained into how these channels affect mental health and cognitive abilities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive deficits related to psychiatric conditions.
Not a fit: Patients with cognitive functions unaffected by psychiatric disorders may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for improving cognitive functions in individuals with psychiatric disorders.
How similar studies have performed: Other research has shown promising results in understanding the role of calcium channels in neuronal activity, suggesting potential for success in this area.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Joksimovic, Srdan — Children's Hosp of Philadelphia
- Study coordinator: Joksimovic, Srdan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.