Investigating how C1QL3 affects brain cell connections
Official title: The Molecular Role of C1QL3 and its Binding Partners in Synaptic Regulation
Funded at University of Connecticut Sch of Med/dnt · NIH-10997468 · Data updated 2026-11-12
This study is looking at how a protein called C1QL3 helps brain cells connect with each other, which is important for conditions like ADHD and autism, to find new ways to improve treatment for these disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $45,419 |
| NIH project number | 1F30MH135628-01A1 |
| Project ID | NIH-10997468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neuropsychiatric disorders such as ADHD or autism.
✕Less likely to help
Patients with neuropsychiatric disorders not related to synaptic dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called C1QL3 in regulating connections between brain cells, which are crucial for proper brain function. By studying how C1QL3 interacts with other proteins at synapses, the research aims to uncover the mechanisms behind synaptic dysfunction in neuropsychiatric disorders like ADHD and autism. The approach involves advanced microscopy techniques to visualize these interactions in neuron cultures, providing insights that could lead to new therapeutic strategies for these conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for neuropsychiatric disorders that improve patients' quality of life.
How similar studies have gone: Previous research has shown promise in targeting synaptic adhesion molecules for therapeutic interventions in neuropsychiatric disorders, indicating a potential for success in this area.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Caro, Keaven Delwyn Jacob — University of Connecticut Sch of Med/dnt
- Study coordinator: Caro, Keaven Delwyn Jacob
Related research
Other NIH-funded projects on the same topics.
-
Mapping the full range of human genome structure variations
Researchers are building better maps of the big and small differences in human DNA to improve precision medicine.
-
Understanding the full spectrum of structural genetic variation in human genomes
Scientists are improving how we detect complex DNA changes across many human genomes to advance precision medicine.
-
Mapping all kinds of genetic differences in human genomes to improve precision medicine
A national researchers team is creating better ways to find and understand big genetic differences in human DNA to help doctors tailor care.
-
Total Worker Health program for safer, healthier workplaces
A large, multi-year program aims to improve worker health and safety by addressing the whole work environment for people in real-world jobs.
-
Nfe2l3 helps retinal cells heal and may restore simple vision after optic nerve injuries
A scientist at a major university studies how a protein called Nfe2l3 could help retinal nerve cells regrow their axons and potentially restore basic vision after optic nerve injuries.
-
Nfe2l3-driven protection and optic nerve repair for vision
This grant explores how a protein called Nfe2l3 might help retinal nerve cells repair damaged optic nerves to restore simple vision after injuries.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.