Investigating how branched-chain amino acids affect kidney function
Official title: Role of branched-chain amino acid catabolism in the proximal tubule
Funded at State University New York Stony Brook · NIH-11010780 · Data updated 2026-11-12
This study is looking at how certain nutrients called branched-chain amino acids affect kidney cells when they are injured, with the hope of finding new ways to help improve kidney health and prevent further damage for people with acute kidney injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $350,900 |
| NIH project number | 5R01DK133238-03 |
| Project ID | NIH-11010780 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing acute kidney injury or those at risk of developing chronic kidney disease.
✕Less likely to help
Patients with stable chronic kidney disease who are not experiencing acute kidney injury may not benefit from this research.
What this research studies
This research focuses on understanding the role of branched-chain amino acids (BCAAs) in the metabolism of kidney cells, particularly in the context of acute kidney injury (AKI). The study examines how the catabolism of BCAAs is altered during kidney injury and how this impacts cellular energy production. By exploring the metabolic pathways involved, the research aims to identify potential therapeutic strategies to improve kidney function and prevent further damage. Patients may benefit from insights that could lead to new treatments for AKI and chronic kidney disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that improve kidney function and reduce the risk of chronic kidney disease in patients with acute kidney injury.
How similar studies have gone: Other research has shown promising results in exploring metabolic pathways in kidney injury, but the specific focus on BCAA catabolism in this context is relatively novel.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Piret, Sian — State University New York Stony Brook
- Study coordinator: Piret, Sian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.