Investigating how brain systems related to stress affect depression and anxiety
Roles of nuleus accumbens CREB and Kappa function in depression
This study is looking at how stress affects depression and anxiety by focusing on certain parts of the brain, and it aims to find new ways to help people feel better by understanding these changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-10893445 on NIH RePORTER |
What this research studies
This research explores the role of specific brain systems, particularly the nucleus accumbens, in how stress influences depression and anxiety. By examining the function of the transcription factor CREB and kappa-opioid receptors, the study aims to understand how these systems change with stress and how they affect behavior. The research includes innovative methods that align testing in animal models with human procedures, potentially leading to new treatments for mood disorders. The findings could inform clinical trials for new medications targeting these brain systems.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing depression or anxiety, particularly those affected by stress or related conditions.
Not a fit: Patients with primary psychotic disorders or those not experiencing mood or anxiety disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for depression and anxiety that are more effective and targeted.
How similar studies have performed: Previous research has shown promise in targeting similar brain systems for treating mood disorders, indicating a potential for success in this approach.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Carlezon, William a. — Mclean Hospital
- Study coordinator: Carlezon, William a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.