Investigating how brain stimulation affects mental health through specific brain circuits
Prefrontal circuit mechanisms of repetitive transcranial magnetic stimulation
This study is looking at how a treatment called rTMS affects brain activity in a specific area linked to mental health, using a special rodent model, to help find better ways to treat conditions like depression and anxiety.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10809027 on NIH RePORTER |
What this research studies
This research explores the effects of repetitive transcranial magnetic stimulation (rTMS) on the prefrontal cortex, a brain region involved in mental health. By using a specialized rodent model, the study aims to understand how rTMS influences the activity of different types of neurons in this area. The researchers will monitor changes in neural activity before, during, and after rTMS application to uncover the mechanisms behind its effects on mental disorders. This could lead to improved treatments for conditions like depression and anxiety.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from major depression, obsessive-compulsive disorder, or other psychiatric conditions that may benefit from brain stimulation therapies.
Not a fit: Patients with neurological disorders unrelated to the prefrontal cortex or those who do not respond to rTMS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted treatments for various mental health disorders.
How similar studies have performed: Previous research has shown promising results with rTMS in treating mental health disorders, indicating that this approach has potential for success.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Wilke, Scott Allen — University of California Los Angeles
- Study coordinator: Wilke, Scott Allen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.