Investigating how brain stimulation affects glial cells
The glial mechanism for electrical brain stimulation
This study is looking at how electrical brain stimulation affects certain brain cells called astrocytes and how these cells release tiny particles that might help improve treatments for neurological disorders, so it could lead to better therapies for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10677022 on NIH RePORTER |
What this research studies
This research explores the effects of electrical brain stimulation on astrocytes, a type of glial cell in the brain. It aims to understand how these cells release extracellular vesicles when stimulated, which may play a role in treating neurological disorders. The study involves characterizing these vesicles, examining the molecular mechanisms behind their release, and testing their functions in both laboratory and animal models. Patients may benefit from insights that could enhance existing neuromodulation therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurological disorders that are currently treated with electrical brain stimulation, such as epilepsy.
Not a fit: Patients with conditions unrelated to neurological disorders or those who do not respond to electrical brain stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for neurological disorders through enhanced understanding of brain stimulation mechanisms.
How similar studies have performed: Previous research has shown promising results in understanding the role of glial cells in brain function, suggesting that this approach may yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Worrell, Gregory a — Mayo Clinic Rochester
- Study coordinator: Worrell, Gregory a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.