Investigating how brain circuits in the amygdala affect stress disorders
Role of amygdala inhibitory circuit neuromodulation in stress disorders
['FUNDING_OTHER'] · SOUTHEAST LOUISIANA VETERANS HEALTH CARE · NIH-11109608
This study is looking at how certain brain circuits in the amygdala, which help us handle emotions, work when we're stressed or dealing with issues like PTSD and alcohol use, to find out how changes in brain signals might help us better understand and treat these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SOUTHEAST LOUISIANA VETERANS HEALTH CARE (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11109608 on ClinicalTrials.gov |
What this research studies
This research explores the role of inhibitory circuits in the amygdala, a brain region involved in emotional processing, particularly in relation to stress disorders like PTSD and alcohol use disorder. By examining how neuromodulation affects the balance of excitation and inhibition in these circuits, the study aims to understand the underlying mechanisms that contribute to emotional memory formation and stress responses. The approach includes preclinical experiments to assess how norepinephrine influences inhibitory inputs in the amygdala, which could lead to new insights into treatment strategies for stress-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with PTSD or alcohol use disorder who are experiencing significant stress-related symptoms.
Not a fit: Patients with stress disorders not related to the amygdala or those without a diagnosis of PTSD or alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals suffering from stress disorders, potentially reducing symptoms and enhancing quality of life.
How similar studies have performed: Other research has shown promising results in understanding the role of neuromodulation in stress disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW ORLEANS, UNITED STATES
- SOUTHEAST LOUISIANA VETERANS HEALTH CARE — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TASKER, JEFFREY G — SOUTHEAST LOUISIANA VETERANS HEALTH CARE
- Study coordinator: TASKER, JEFFREY G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: alcohol use disorder