Investigating how brain cell dysfunction affects alcohol use disorder
Role of parasubthalamic astrocytic dysfunction in alcohol use disorder
This study is looking at how certain brain cells might be affected by alcohol use disorder and how a specific protein could influence mood and addiction, with the hope of finding new treatments that could help people dealing with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11093539 on NIH RePORTER |
What this research studies
This research explores the role of astrocytes, a type of brain cell, in alcohol use disorder by examining how their dysfunction may contribute to the condition. Using a mouse model, the study investigates the effects of a specific protein, RGS12, on serotonin transporters, which are involved in mood and addiction. By understanding these mechanisms, the research aims to identify potential new treatment strategies for individuals struggling with alcohol use disorder. Patients may benefit from insights that could lead to the development of effective therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder or those at risk of developing it.
Not a fit: Patients who do not have alcohol use disorder or related stimulant use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for individuals with alcohol use disorder.
How similar studies have performed: Previous research has shown promise in targeting similar pathways for addiction treatment, suggesting potential for success in this approach.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: White, Allison — Scripps Research Institute, the
- Study coordinator: White, Allison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.