Investigating how bone marrow affects cardiovascular disease
PROJECT 2: Cardiovascular disease (CVD) and the stromal bone marrow niche
This study is looking at how the bone marrow helps make immune cells that can affect heart health, especially after issues like heart attacks or high blood pressure, to find new ways to prevent or manage heart disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11012930 on NIH RePORTER |
What this research studies
This research explores the role of the bone marrow environment in the production of immune cells that contribute to cardiovascular disease (CVD). The team will study how conditions like heart attacks and hypertension influence the formation of new blood vessels and immune cell clusters in the bone marrow. By using specialized mouse models, they aim to understand the mechanisms behind increased immune cell production and its impact on heart health. This research could lead to new insights into how to manage or prevent CVD by targeting the bone marrow's role in inflammation and immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiovascular disease, particularly those who have experienced heart attacks or have hypertension.
Not a fit: Patients without cardiovascular disease or those who do not have risk factors for heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve heart health in patients with cardiovascular disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of the bone marrow in cardiovascular disease, indicating that this approach has potential for significant findings.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Nahrendorf, Matthias — Massachusetts General Hospital
- Study coordinator: Nahrendorf, Matthias
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.