Investigating how blood platelets affect brain cancer progression
Official title: A Hyper-Thrombotic State and Immunosuppression in GBM
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10994351 · Data updated 2026-11-12
This study is looking at how high blood platelet counts might affect the growth of glioblastoma, a tough type of brain cancer, and how this could be different for men and women, with the goal of finding new ways to help patients live longer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $75,928 |
| NIH project number | 1F32CA287655-01A1 |
| Project ID | NIH-10994351 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who may have elevated platelet counts.
✕Less likely to help
Patients with other types of cancer or those without elevated platelet counts may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between high blood platelet counts and the progression of glioblastoma (GBM), a common and aggressive brain cancer. It aims to explore how a hyper-thrombotic state, characterized by increased platelet activity, contributes to tumor growth and poor clinical outcomes in GBM patients. The study will also examine the role of sex differences in platelet behavior and their interaction with immune cells in the tumor microenvironment. By using murine models, the researchers will investigate potential therapeutic targets to improve survival rates, particularly in female patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve survival rates for patients with glioblastoma by targeting platelet activity.
How similar studies have gone: Other research has shown promising results in targeting platelet activity in cancer treatment, suggesting potential for success in this approach.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Sloan, Anthony Robert — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Sloan, Anthony Robert
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Understanding and Overcoming T cell Immunosuppression in Glioblastoma (GBM)
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.