Investigating how blood cell mutations affect heart disease risk
Official title: Integrated omics analysis of clonal hematopoiesis and cardiovascular disease risk in TOPMed
Funded at Emory University · NIH-10890887 · Data updated 2026-11-12
This study is looking at how certain changes in your blood cells might increase the risk of heart disease, and it's for anyone interested in understanding the connection between genetics and heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 19, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $624,385 |
| NIH project number | 5R01HL168894-02 |
| Project ID | NIH-10890887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who may have clonal hematopoiesis and are at risk for cardiovascular diseases.
✕Less likely to help
Patients who are younger than 21 years old or do not have clonal hematopoiesis may not benefit from this research.
What this research studies
This research explores the relationship between clonal hematopoiesis, a condition where certain blood cells gain mutations, and the risk of developing atherosclerotic cardiovascular disease (ASCVD). By analyzing blood samples from a large group of individuals, the study aims to identify specific genetic and molecular changes associated with these mutations. The researchers will utilize advanced techniques to examine DNA methylation and RNA splicing patterns, which may help clarify how these mutations contribute to heart disease risk. This comprehensive approach could lead to a better understanding of the biological mechanisms linking blood cell mutations to cardiovascular health.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted prevention strategies for cardiovascular disease in individuals with clonal hematopoiesis.
How similar studies have gone: Previous research has shown promising results in understanding the genetic factors associated with cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Conneely, Karen — Emory University
- Study coordinator: Conneely, Karen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.