Investigating how beta cell communication affects diabetes
Beta cell extracellular vesicles in health and disease
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10782463
This study is looking at tiny particles from insulin-producing cells in the pancreas to see how they help cells talk to each other and change when the pancreas is under stress, with the hope of finding new ways to improve diabetes treatments for people living with the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10782463 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of beta cell-derived extracellular vesicles in diabetes. It aims to explore how these vesicles communicate between cells and how their contents change in response to stress and inflammation in the pancreas. By identifying the signaling pathways involved, the research seeks to uncover new biomarkers and potential therapies that could improve beta cell function and survival. Patients may benefit from insights that could lead to innovative treatments for various forms of diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Type 1 diabetes or other forms of diabetes characterized by beta cell dysfunction.
Not a fit: Patients with diabetes types not related to beta cell failure, such as Type 2 diabetes primarily driven by insulin resistance, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance beta cell health and function, potentially improving diabetes management.
How similar studies have performed: Previous research has shown promise in understanding the role of extracellular vesicles in cell communication, suggesting that this approach could yield valuable insights.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMS, EMILY K — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: SIMS, EMILY K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Juvenile-Onset Diabetes Mellitus, Ketosis-Prone Diabetes Mellitus, Sudden-Onset Diabetes Mellitus, T1 diabetes, Type 1 Diabetes Mellitus