Investigating how autophagy affects the maturation of arteriovenous fistulas for dialysis.
Autophagy and Arteriovenous Fistula Maturation
This study is looking into why some arteriovenous fistulas (AVFs) don’t develop as they should for people on hemodialysis, and it aims to find ways to help them mature better by understanding how certain cellular processes work, especially for those with chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10831413 on NIH RePORTER |
What this research studies
This research focuses on understanding why arteriovenous fistulas (AVFs), which are crucial for hemodialysis patients, often fail to mature properly. The study aims to explore the role of autophagy, a cellular process, in the maturation of AVFs, particularly in patients with chronic kidney disease. By examining the effects of disturbed blood flow and the cellular mechanisms involved, the researchers hope to identify new therapeutic strategies to enhance AVF maturation and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients undergoing hemodialysis who are at risk of arteriovenous fistula maturation failure.
Not a fit: Patients who do not require hemodialysis or have alternative vascular access methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved techniques for ensuring that arteriovenous fistulas mature effectively, thereby enhancing the quality of life for hemodialysis patients.
How similar studies have performed: While the specific approach of investigating autophagy in AVF maturation is novel, related studies have shown promise in understanding vascular access dysfunction.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Lee, Timmy C — University of Alabama at Birmingham
- Study coordinator: Lee, Timmy C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.