Investigating how arsenic and ultraviolet radiation together increase cancer risk
Mutational Signatures of a Combined Environmental Exposure: Arsenic and Ultraviolet Radiation
['FUNDING_R01'] · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · NIH-10869994
This study is looking at how exposure to arsenic and UV light together might increase the risk of skin cancer, and it hopes to find ways to help prevent these cancers in people who might be affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR (nih funded) |
| Locations | 1 site (ALBUQUERQUE, UNITED STATES) |
| Trial ID | NIH-10869994 on ClinicalTrials.gov |
What this research studies
This research explores the effects of arsenic exposure combined with ultraviolet radiation on cancer development. It aims to understand the molecular mechanisms by which arsenic acts as a co-carcinogen, particularly in skin cancers. Using advanced next-generation sequencing techniques, the study will analyze mutational signatures in tumors to identify specific DNA repair defects caused by these environmental factors. Patients may benefit from insights that could lead to better prevention strategies for arsenic-related cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to arsenic in drinking water and are at risk for skin cancer.
Not a fit: Patients who have not been exposed to arsenic or do not have a history of skin cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies for skin cancers associated with arsenic exposure.
How similar studies have performed: Previous research has shown that environmental factors like arsenic can increase cancer risk, but this specific combination with ultraviolet radiation is still being explored.
Where this research is happening
ALBUQUERQUE, UNITED STATES
- UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR — ALBUQUERQUE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUDSON, LAURIE G — UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- Study coordinator: HUDSON, LAURIE G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer, Cancer Causing Agents, Skin Cancer