Investigating how antiviral responses affect bacterial sepsis
The role of antiviral programs in bacterial sepsis
This study is looking at how inflammation affects the body's ability to fight off viruses in people with bacterial sepsis, which can cause serious kidney problems, and aims to find better treatments to help those patients recover.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10894114 on NIH RePORTER |
What this research studies
This research explores the complex relationship between inflammation and antiviral responses in patients suffering from bacterial sepsis, a condition that can lead to acute kidney injury and high mortality rates. By studying animal models, the researchers aim to understand how the body's inflammatory response can trigger antiviral programs even in the absence of viral infections. The goal is to identify specific timelines and mechanisms that could lead to more effective, targeted therapies for sepsis. This work could ultimately help in developing treatments that address the underlying causes of organ failure in sepsis patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing bacterial sepsis, particularly those at risk for acute kidney injury.
Not a fit: Patients with sepsis caused by viral infections or those with chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates and outcomes for patients with sepsis.
How similar studies have performed: Previous research has shown promising results in understanding the inflammatory responses in sepsis, but the specific focus on antiviral programs in this context is relatively novel.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Hato, Takashi — Indiana University Indianapolis
- Study coordinator: Hato, Takashi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.