Investigating how aging affects cell structure and function
Official title: Tubulin modifications and cytoskeletal alterations in aging
Funded at New York University School of Medicine · NIH-10783747 · Data updated 2026-11-12
This study is looking at how cells change as they get older, especially in people with Hutchinson-Gilford progeria syndrome, to understand how certain proteins help keep cells healthy and stable, which could lead to new ways to help with aging-related issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $211,875 |
| NIH project number | 5R21AG076470-02 |
| Project ID | NIH-10783747 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with premature aging syndromes or those experiencing age-related cellular dysfunction.
✕Less likely to help
Patients who are not experiencing any aging-related conditions or cellular abnormalities may not benefit from this research.
What this research studies
This research explores the changes in cell structure, specifically the cytoskeleton, that occur as cells age. It focuses on understanding the roles of specific proteins that maintain normal cell shape and function, particularly in relation to a condition known as Hutchinson-Gilford progeria syndrome, which mimics premature aging. By examining how these proteins influence the stability and modifications of tubulin, the study aims to uncover the underlying mechanisms of aging at the cellular level. Patients may benefit from insights gained about aging-related cellular defects and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases and conditions associated with premature aging.
How similar studies have gone: Previous research has shown promising results in understanding cellular aging mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Dynlacht, Brian D — New York University School of Medicine
- Study coordinator: Dynlacht, Brian D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.