Investigating how aging affects auditory neurons at a cellular level
Official title: Proteomic Core D
Funded at University of Arizona · NIH-10910238 · Data updated 2026-11-12
This study is looking at how the tiny nerve cells in your ears change as you get older, which can help explain why some people experience hearing loss as they age.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $115,369 |
| NIH project number | 7P01AG051443-07 |
| Project ID | NIH-10910238 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing hearing loss or those with age-related auditory changes.
✕Less likely to help
Patients with hearing loss due to non-aging related factors, such as noise exposure or genetic conditions, may not benefit from this research.
What this research studies
This research focuses on understanding the biochemical changes that occur in auditory neurons as they age, specifically targeting spiral ganglion neurons and cochlear nuclei neuron subtypes. By utilizing advanced liquid chromatography-mass spectrometry techniques, the study aims to analyze the proteomic profiles of these neurons at a single-cell resolution. This approach will help identify the specific alterations in protein composition that contribute to age-related hearing loss, providing insights into the underlying mechanisms of auditory neural aging.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for age-related hearing loss.
How similar studies have gone: Previous research has shown promise in using proteomic approaches to study cellular changes in various conditions, suggesting potential for success in this novel application.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Pasa-Tolic, Ljiljana — University of Arizona
- Study coordinator: Pasa-Tolic, Ljiljana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.