Investigating how age affects immune cell function in viral pneumonia recovery
Project 4: Epigenetic modifiers of regulatory T cell function following viral pneumonia
['FUNDING_P01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10910896
This study is looking at how older adults recover from severe lung infections like those caused by the flu and COVID-19, focusing on special immune cells that help heal the lungs, to find better ways to support their recovery and improve their health.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10910896 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how older patients recover from severe viral pneumonia caused by influenza and COVID-19. It examines the role of specific immune cells, known as regulatory T cells, which help in the healing process after lung injury. By studying the changes in these cells due to aging, the research aims to identify ways to enhance recovery and improve health outcomes for older patients suffering from acute respiratory distress syndrome (ARDS). The approach involves analyzing the genetic and epigenetic factors that influence the function of these immune cells in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced severe viral pneumonia, particularly those with acute respiratory distress syndrome.
Not a fit: Patients who are younger or do not have a history of severe viral pneumonia may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for older patients suffering from severe viral pneumonia, potentially reducing ICU stays and enhancing overall health outcomes.
How similar studies have performed: Previous research has shown promising results in enhancing recovery in older patients with similar immune modulation approaches, indicating potential for success in this study.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SINGER, BENJAMIN DAVID — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: SINGER, BENJAMIN DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome