Investigating how adolescent binge drinking affects brain cells and behavior differently in males and females
Sex differences in somatostatin cell dynamics and exploratory behavior after adolescent binge drinking in mice
This study looks at how binge drinking during the teenage years affects brain cells and behavior, especially how it differs between boys and girls, using mice to help us understand the risks of addiction and thinking problems in young people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project ID | NIH-11045596 on NIH RePORTER |
What this research studies
This research explores the effects of adolescent binge drinking on brain cells and behavior, focusing on sex differences. Using a mouse model, the study examines how alcohol consumption alters somatostatin cell dynamics in the brain and how these changes relate to exploratory behavior. Researchers will utilize advanced techniques such as patch-clamp electrophysiology and neuroimaging to assess the impact of alcohol on brain function and behavior over time. The goal is to better understand the underlying mechanisms that contribute to addiction and cognitive dysfunction in adolescents.
Who could benefit from this research
Good fit: Ideal candidates for this research are adolescents aged 12-20 who have experienced binge drinking or are at risk for alcohol use disorders.
Not a fit: Patients who are not adolescents or who have not engaged in binge drinking may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for alcohol-related issues in adolescents.
How similar studies have performed: Previous research has shown that understanding sex differences in addiction can lead to more effective treatment approaches, indicating potential success for this study's approach.
Where this research is happening
University Park, United States
- Pennsylvania State University, the — University Park, United States (Active)
Researchers
- Principal investigator: Seemiller, Laurel — Pennsylvania State University, the
- Study coordinator: Seemiller, Laurel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.