Investigating how ABO blood type affects the risk of Acute Respiratory Distress Syndrome in sepsis
An ABO Blood Type Defined ARDS Endotype in Sepsis
This study is looking at how your blood type might affect your chances of developing Acute Respiratory Distress Syndrome (ARDS) if you have sepsis, with the goal of finding better ways to understand and treat patients who are at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10904744 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between ABO blood types and the risk of developing Acute Respiratory Distress Syndrome (ARDS) in patients with sepsis. It examines how genetic variations in blood type influence the body's response to inflammation and coagulation, which are critical factors in ARDS. By analyzing blood samples and associated proteins, the study aims to identify specific blood type-related risks and mechanisms that contribute to ARDS. This could lead to better risk stratification and targeted therapies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with sepsis who have varying ABO blood types, particularly those with blood type A.
Not a fit: Patients who do not have sepsis or those with blood type O may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification of patients at higher risk for ARDS and the development of targeted treatments.
How similar studies have performed: Previous research has shown associations between blood type and various health risks, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Reilly, John Patrick — University of Pennsylvania
- Study coordinator: Reilly, John Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.