Investigating how a specific signaling pathway affects kidney cell injury
The contribution of the APOM/S1P signaling axis to podocyte injury
This study is looking at how certain signals in the body can harm important kidney cells called podocytes, which might help us understand kidney diseases better and find new ways to protect these cells.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11094689 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the APOM/S1P signaling axis in causing injury to podocytes, which are essential cells in the kidneys. The study aims to identify a common pathway that regulates lipid metabolism and cholesterol transport in these cells, which may contribute to the progression of various kidney diseases. By analyzing gene expression and lipid profiles in both human patients and mouse models, the researchers hope to uncover mechanisms that lead to podocyte damage and kidney dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with glomerular diseases, particularly those with Alport syndrome or similar hereditary nephritis.
Not a fit: Patients with kidney diseases not related to podocyte injury or those without a genetic predisposition to glomerular diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating kidney diseases associated with podocyte injury.
How similar studies have performed: Previous research has shown promising results in understanding lipid-induced podocyte injury, suggesting that this approach may yield valuable insights.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Tolerico, Matthew Robert — University of Miami School of Medicine
- Study coordinator: Tolerico, Matthew Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.