Investigating how a specific signaling pathway affects kidney cell injury
Official title: The contribution of the APOM/S1P signaling axis to podocyte injury
Funded at University of Miami School of Medicine · NIH-11094689 · Data updated 2026-11-12
This study is looking at how certain signals in the body can harm important kidney cells called podocytes, which might help us understand kidney diseases better and find new ways to protect these cells.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | May 16, 2024 |
| Project end | May 15, 2027 |
| Funding year | 2025 |
| Award (this year) | $43,138 |
| NIH project number | 5F31DK137425-02 |
| Project ID | NIH-11094689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with glomerular diseases, particularly those with Alport syndrome or similar hereditary nephritis.
✕Less likely to help
Patients with kidney diseases not related to podocyte injury or those without a genetic predisposition to glomerular diseases may not benefit from this research.
What this research studies
This research focuses on understanding the role of the APOM/S1P signaling axis in causing injury to podocytes, which are essential cells in the kidneys. The study aims to identify a common pathway that regulates lipid metabolism and cholesterol transport in these cells, which may contribute to the progression of various kidney diseases. By analyzing gene expression and lipid profiles in both human patients and mouse models, the researchers hope to uncover mechanisms that lead to podocyte damage and kidney dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating kidney diseases associated with podocyte injury.
How similar studies have gone: Previous research has shown promising results in understanding lipid-induced podocyte injury, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Tolerico, Matthew Robert — University of Miami School of Medicine
- Study coordinator: Tolerico, Matthew Robert
Related research
Other NIH-funded projects on the same topics.
-
Decoding how GAA repeats in FGF14 cause SCA27B
This project looks at why a specific DNA repeat in the FGF14 gene leads to Spinocerebellar Ataxia 27B in adults.
-
Breathing therapy to help clear brain toxins in older adults who sleep poorly
A small study will test a breathing-based therapy to boost brain toxin clearance in older adults with poor sleep patterns related to Alzheimer’s risk.
-
New retinal imaging to detect brain small vessel disease
A fast, wide-field eye imaging method will measure how tiny retinal blood vessels rhythmically flow to help detect early brain small vessel disease.
-
Understanding the Genetics Behind IBD in South Florida
This grant looks at how genes and the environment come together to influence inflammatory bowel disease in people living in South Florida.
-
MorpHiC Data Resource and Coordinating Center
A national effort to build and share a comprehensive, high-quality catalogue of how human genes affect cell function when they’re turned off, using human cellular models.
-
MorPhiC data hub for gene function in human cells
A data resource and coordinating center will organize and share information about how human genes affect cellular traits when knocked out, helping researchers understand gene functions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.