Investigating how a specific RNA helps the body fight tuberculosis infection
The role of FENDRR in host defense against Mycobacterium tuberculosis infection
This study is looking at how a special molecule called FENDRR helps our immune system fight off tuberculosis, the bacteria that causes TB, by working with immune cells, and it aims to find new ways to improve treatment for people with this infection.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma State University Stillwater NIH-funded |
| Lab location | 1 site (Stillwater, United States) |
| Project ID | NIH-10888257 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a long noncoding RNA called FENDRR in the body's defense against Mycobacterium tuberculosis, the bacteria that causes tuberculosis. Researchers will explore how FENDRR interacts with immune cells, particularly macrophages, to enhance the body's response to this infection. By studying these interactions in both mouse and human cells, the goal is to uncover new therapeutic strategies that could improve treatment for tuberculosis. The research involves laboratory experiments to observe the effects of FENDRR on bacterial growth and immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently infected with tuberculosis.
Not a fit: Patients with non-infectious diseases or those who do not have a history of tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new host-directed therapies that enhance the immune response against tuberculosis, potentially reducing the disease's impact.
How similar studies have performed: While the role of long noncoding RNAs in immune responses is a growing field, the specific investigation of FENDRR in tuberculosis is relatively novel and has not been extensively tested.
Where this research is happening
Stillwater, United States
- Oklahoma State University Stillwater — Stillwater, United States (Active)
Researchers
- Principal investigator: Cheng, Yong — Oklahoma State University Stillwater
- Study coordinator: Cheng, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.