Investigating how a specific receptor affects heart protection during ischemic injury.
Free fatty acid receptor 4 cardioprotective effects in cardiac ischemic injury
This study is looking at how a specific receptor in the heart responds to omega-3 fatty acids, like those found in fish oil, to see if they can help protect the heart from damage caused by heart disease, which could lead to new ways to improve heart health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10800702 on NIH RePORTER |
What this research studies
This research explores the role of free fatty acid receptor 4 (Ffar4) in protecting the heart from damage caused by coronary heart disease and myocardial infarction. It examines how omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), interact with this receptor to potentially improve heart function and reduce fibrosis. The study involves both animal models and cellular experiments to understand the mechanisms behind these protective effects. Patients may benefit from insights gained about dietary interventions and new therapeutic targets for heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are at risk for or currently suffering from cardiovascular diseases.
Not a fit: Patients with non-cardiovascular related health issues or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from coronary heart disease and heart failure.
How similar studies have performed: Previous studies have shown promising results with high-dose omega-3 fatty acids in improving heart outcomes, suggesting that this approach may be effective.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: O'connell, Timothy D — University of Minnesota
- Study coordinator: O'connell, Timothy D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.