Investigating how a specific protein receptor affects immune cell stability in autoimmune diseases
Official title: Bone Morphogenic Protein Receptor 1a signaling controls stability of Treg cell phenotype
Funded at Old Dominion University · NIH-10892293 · Data updated 2026-11-12
This study is looking at how a specific protein, BMPR1α, helps keep immune cells called T regulatory cells stable and working well, which could lead to new ways to treat autoimmune diseases and help people maintain a balanced immune system.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Old Dominion University NIH-funded |
| Lab location | 1 site (Norfolk, United States) |
| Project start | July 21, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $200,569 |
| NIH project number | 5R21AI178316-02 |
| Project ID | NIH-10892293 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune diseases who may benefit from improved immune regulation.
✕Less likely to help
Patients with non-autoimmune conditions or those not experiencing immune dysregulation may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of Bone Morphogenetic Protein Receptor 1α (BMPR1α) in regulating immune cells, particularly T regulatory cells (Tregs) that help maintain immune balance. The study examines how BMPR1α influences the stability of Treg cells and their ability to prevent autoimmune responses. By analyzing the signaling pathways and cellular changes associated with BMPR1α, researchers aim to uncover mechanisms that could lead to new treatments for autoimmune diseases. Patients may benefit from insights gained about how to enhance immune tolerance and prevent disease progression.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases by enhancing the stability and function of regulatory immune cells.
How similar studies have gone: Previous research has shown promising results in understanding immune regulation through similar signaling pathways, suggesting potential for success in this area.
Where this research is happening
-
Old Dominion University
Norfolk, United States Active
Researchers
- Principal investigator: Kraj, Piotr J. — Old Dominion University
- Study coordinator: Kraj, Piotr J.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.