Investigating how a specific protein in T cells relates to Inflammatory Bowel Disease
Official title: Genetic studies linking LSP1 function in T cells to Inflammatory Bowel Disease
Funded at La Jolla Institute for Immunology · NIH-11010811 · Data updated 2026-11-12
This study is looking at how a specific protein in immune cells might affect Inflammatory Bowel Disease (IBD), with the hope of finding new ways to help people with this condition feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $362,340 |
| NIH project number | 5R01DK135683-03 |
| Project ID | NIH-11010811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Inflammatory Bowel Disease, particularly those with active symptoms.
✕Less likely to help
Patients who do not have Inflammatory Bowel Disease or those with other unrelated autoimmune conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of the Leukocyte-specific protein 1 (LSP1) in T cells and its connection to Inflammatory Bowel Disease (IBD). By examining activated CD4+ T cells, the researchers aim to identify genetic variants that influence the function of these immune cells in the context of IBD. The study employs advanced techniques such as single-cell expression quantitative trait loci (eQTL) analysis to uncover how variations in LSP1 levels may affect T cell behavior and contribute to disease progression. Patients may benefit from insights that could lead to new therapeutic targets for IBD.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that more effectively manage or even prevent Inflammatory Bowel Disease.
How similar studies have gone: Previous studies have shown promise in identifying genetic factors related to autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
La Jolla Institute for Immunology
La Jolla, United States Active
Researchers
- Principal investigator: Schmiedel, Benjamin Joachim — La Jolla Institute for Immunology
- Study coordinator: Schmiedel, Benjamin Joachim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.