Investigating how a specific protein in T cells relates to Inflammatory Bowel Disease
Genetic studies linking LSP1 function in T cells to Inflammatory Bowel Disease
This study is looking at how a specific protein in immune cells might affect Inflammatory Bowel Disease (IBD), with the hope of finding new ways to help people with this condition feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11010811 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the Leukocyte-specific protein 1 (LSP1) in T cells and its connection to Inflammatory Bowel Disease (IBD). By examining activated CD4+ T cells, the researchers aim to identify genetic variants that influence the function of these immune cells in the context of IBD. The study employs advanced techniques such as single-cell expression quantitative trait loci (eQTL) analysis to uncover how variations in LSP1 levels may affect T cell behavior and contribute to disease progression. Patients may benefit from insights that could lead to new therapeutic targets for IBD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Inflammatory Bowel Disease, particularly those with active symptoms.
Not a fit: Patients who do not have Inflammatory Bowel Disease or those with other unrelated autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that more effectively manage or even prevent Inflammatory Bowel Disease.
How similar studies have performed: Previous studies have shown promise in identifying genetic factors related to autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- La Jolla Institute for Immunology — La Jolla, United States (Active)
Researchers
- Principal investigator: Schmiedel, Benjamin Joachim — La Jolla Institute for Immunology
- Study coordinator: Schmiedel, Benjamin Joachim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.