Investigating how a specific protein in B cells affects autoimmune responses in the central nervous system.
Official title: Role of Tim-l in B Cells in regulating autoimmunity in the CNS
Funded at Brigham and Women's Hospital · NIH-11123350 · Data updated 2026-11-12
This study is looking at a protein called Tim-1 in B cells to see how it affects the immune system and could help us find new treatments for autoimmune diseases that cause inflammation, especially in the nervous system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 21, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $631,364 |
| NIH project number | 5R01AI185514-02 |
| Project ID | NIH-11123350 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune diseases, particularly those affecting the central nervous system.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by central nervous system disorders may not benefit from this research.
What this research studies
This research explores the role of Tim-1, a protein found on B cells, in regulating immune responses related to autoimmune diseases. By studying genetically modified mice that lack Tim-1 in their B cells, researchers aim to understand how this protein influences the production of IL-10, an important anti-inflammatory molecule. The study will also investigate the mechanisms that lead to the generation of regulatory B cells and how these cells can help control inflammation and autoimmunity in the central nervous system. Patients may benefit from insights gained about potential new treatments for autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing autoimmune diseases by enhancing the body's natural regulatory mechanisms.
How similar studies have gone: Previous research has shown promising results in understanding the role of B cells in autoimmunity, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Kuchroo, Vijay K. — Brigham and Women's Hospital
- Study coordinator: Kuchroo, Vijay K.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.