Investigating how a specific protein affects influenza virus infections in the lungs
Molecular Mechanisms and In Vivo Impact of Tethered Mucin 1-Influenza Virus Interactions
['FUNDING_R01'] · UNIV OF MARYLAND, COLLEGE PARK · NIH-11010831
This study is looking at how a protein called MUC1 on the surface of lung cells affects how the flu virus infects those cells, and it’s for anyone interested in understanding more about how the flu works in our bodies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MARYLAND, COLLEGE PARK (nih funded) |
| Locations | 1 site (COLLEGE PARK, UNITED STATES) |
| Trial ID | NIH-11010831 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a protein called MUC1 in how the influenza A virus infects airway epithelial cells. The study aims to explore how MUC1, which can be found on the surface of these cells, interacts with the virus and influences its ability to cause infection. Researchers will create a detailed map of MUC1 expression in the lungs during infection and examine how this protein's presence affects the virus's behavior. By using advanced biological techniques, they hope to uncover the complex mechanisms behind MUC1's role in viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with respiratory conditions or those who are at higher risk for influenza infections.
Not a fit: Patients who do not have respiratory issues or are not at risk for influenza may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating influenza infections by targeting MUC1 interactions.
How similar studies have performed: Previous research has shown that understanding protein interactions in viral infections can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
COLLEGE PARK, UNITED STATES
- UNIV OF MARYLAND, COLLEGE PARK — COLLEGE PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCULL, MARGARET ADELE — UNIV OF MARYLAND, COLLEGE PARK
- Study coordinator: SCULL, MARGARET ADELE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection, bacteria infection, bacterial disease, Bacterial Infections