Investigating how a specific protein affects bladder control after spinal cord injury
Role of proNGF-p75 signaling in the bladder control after spinal cord injury
This study is looking at how a protein called proNGF affects bladder control after a spinal cord injury, and it’s testing a new treatment that could help improve bladder function for people dealing with this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10604309 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of proNGF-p75 signaling in bladder control following spinal cord injury. It aims to explore how the protein proNGF, which is released after such injuries, impacts bladder function and sensitivity. The study involves using a small molecule to block the interaction of proNGF with its receptor, which has shown promising results in animal models by improving bladder reflexes and function. By examining these mechanisms, the research seeks to identify potential new treatments for bladder dysfunction in patients with spinal cord injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced spinal cord injuries and are facing bladder control challenges.
Not a fit: Patients with bladder control issues not related to spinal cord injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients suffering from bladder control issues after spinal cord injuries.
How similar studies have performed: Previous research has shown that targeting NGF signaling can lead to improvements in bladder function, suggesting that this approach may be promising.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Gao, Jie — Ohio State University
- Study coordinator: Gao, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.