Investigating how a specific molecule in blood vessel cells affects cholesterol buildup
Identifying an Atherogenic Role for Vascular Smooth Muscle Cell miR-33a Expression
This study is looking at a tiny molecule called miR-33a in blood vessel cells to see if blocking it can help get rid of cholesterol buildup in arteries, which could lower the chances of heart attacks and strokes, and if it works, it might lead to new treatments for patients.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project ID | NIH-10202932 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of miR-33a, a molecule found in vascular smooth muscle cells, in the development of atherosclerosis, a condition characterized by cholesterol accumulation in arteries. The study aims to determine if inhibiting miR-33a can enhance the removal of cholesterol from these cells, potentially reducing the risk of heart attacks and strokes. The research involves both laboratory experiments with cultured cells and tests in mouse models to observe the effects of miR-33a deletion on cholesterol levels and artery health. Patients may benefit from new therapies targeting this mechanism if successful.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis, including those with high cholesterol or a family history of cardiovascular disease.
Not a fit: Patients who do not have atherosclerosis or related cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of heart attacks and strokes by preventing cholesterol buildup in arteries.
How similar studies have performed: Previous research has shown promising results in targeting similar molecular pathways to reduce cholesterol accumulation, suggesting potential for success in this approach.
Where this research is happening
Clemson, United States
- Clemson University — Clemson, United States (Active)
Researchers
- Principal investigator: Stamatikos, Alexis — Clemson University
- Study coordinator: Stamatikos, Alexis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.