Investigating how a specific microRNA affects brain signaling and metabolism
Official title: Metabolic miR-137 Effects Contribute to Neuronal Signaling
Funded at Colorado State University · NIH-11072381 · Data updated 2026-11-12
This study is looking at a tiny molecule in the brain called miR-137 to see how it affects brain signaling and metabolism, especially in people with Schizophrenia and Bipolar Disorder, and it hopes to find new ways to improve treatments for these conditions by understanding how brain health and metabolism are connected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | February 3, 2025 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $185,165 |
| NIH project number | 1R21MH139202-01 |
| Project ID | NIH-11072381 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Schizophrenia or Bipolar Disorder, particularly those experiencing metabolic complications.
✕Less likely to help
Patients without neuropsychiatric disorders or significant metabolic issues may not receive direct benefits from this research.
What this research studies
This research focuses on the role of microRNA miR-137, which is found in high levels in the brain and is linked to conditions like Schizophrenia and Bipolar Disorder. The study aims to understand how miR-137 influences both neuronal signaling and metabolic processes, particularly in relation to obesity and Type II Diabetes. Using a model organism called Drosophila, researchers will explore the connections between metabolic dysfunction and neuropsychiatric symptoms, with the goal of uncovering mechanisms that could lead to better treatments. Patients with these conditions may benefit from insights gained about the interplay between metabolism and brain health.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with neuropsychiatric disorders and metabolic issues.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in metabolic and neuronal functions, suggesting potential for success in this area.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Tsunoda, Susan L — Colorado State University
- Study coordinator: Tsunoda, Susan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.