Investigating how a specific gene influences smooth muscle cells and heart disease risk
PDGFD regulates a transcriptional network to modulate smooth muscle cell transition and coronary artery disease risk
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-10808095
This study is looking at how a specific gene called PDGFD affects heart health by influencing the way certain cells in the blood vessels change and work, which could help us understand more about coronary artery disease and how to prevent it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10808095 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the PDGFD gene in coronary artery disease (CAD) by examining how it affects the transition of smooth muscle cells into different cell types that contribute to heart health. The study employs various mechanistic approaches to explore how PDGFD regulates other genes associated with CAD and how these interactions influence the risk of developing heart disease. By identifying the transcription factors involved in these processes, the research aims to uncover new insights into the cellular mechanisms that underlie CAD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for coronary artery disease, particularly those with genetic predispositions.
Not a fit: Patients without any risk factors for coronary artery disease or those with established heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating coronary artery disease by targeting specific genetic pathways.
How similar studies have performed: Previous research has shown success in understanding genetic factors related to coronary artery disease, making this approach promising but still exploring novel aspects.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QUERTERMOUS, THOMAS — STANFORD UNIVERSITY
- Study coordinator: QUERTERMOUS, THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease, atherosclerotic disease, atherosclerotic vascular disease