Investigating how a specific gene affects brain development in children
Understanding the Role of EIF4A2 in Neurodevelopment
This study is looking at how a gene called EIF4A2 affects brain development in children with neurodevelopmental disorders by using zebrafish to see what happens when this gene is changed, which could help us find better ways to understand and treat these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10949537 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the EIF4A2 gene in neurodevelopmental disorders, particularly in children. By using zebrafish as a model, researchers will explore how changes in this gene can impact the development of brain cells, specifically interneurons, which are crucial for proper brain function. The study employs advanced techniques like CRISPR gene editing to observe the effects of both loss and gain of function of the EIF4A2 gene on brain development. This research aims to uncover the mechanisms behind these changes and their timing, which could lead to better understanding and treatment of related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who are diagnosed with neurodevelopmental disorders such as autism or intellectual disabilities.
Not a fit: Patients with neurodevelopmental disorders not linked to genetic factors or those over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for neurodevelopmental disorders in children.
How similar studies have performed: Other research has shown promising results using similar genetic editing approaches in model organisms, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Duncan, Anna Ruth — Massachusetts General Hospital
- Study coordinator: Duncan, Anna Ruth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.