Investigating how a specific enzyme affects the virulence of cholera bacteria.
The role of NQR in ROS-dependent virulence regulation in Vibrio cholerae
This study looks at how a specific enzyme in the cholera bacteria helps it survive and cause illness in people, with the hope of finding better ways to manage or prevent cholera infections.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon State University NIH-funded |
| Lab location | 1 site (Corvallis, United States) |
| Project ID | NIH-10862704 on NIH RePORTER |
What this research studies
This research explores the relationship between the metabolism of Vibrio cholerae, the bacteria that causes cholera, and its ability to cause disease. It focuses on how the enzyme NQR influences the production of virulence factors in response to oxidative stress. By examining the role of membrane bioenergetics and reactive oxygen species, the study aims to uncover mechanisms that allow the bacteria to adapt and thrive in the human host. Patients may benefit from insights gained into how cholera infections can be better managed or prevented.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals at risk of cholera infection, particularly in areas with poor sanitation.
Not a fit: Patients who are not at risk of cholera or those with established cholera infections may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cholera infections.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown that understanding bacterial metabolism can lead to breakthroughs in managing infectious diseases.
Where this research is happening
Corvallis, United States
- Oregon State University — Corvallis, United States (Active)
Researchers
- Principal investigator: Hase, Claudia C — Oregon State University
- Study coordinator: Hase, Claudia C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.