Investigating how a specific enzyme affects lung injury in ARDS
Official title: Macrophage NUDT21-mediated alternative polyadenylation in lung injury
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11001576 · Data updated 2026-11-12
This study is looking at how a certain enzyme called NUDT21 affects lung inflammation and injury in people with acute respiratory distress syndrome (ARDS), with the hope of finding new ways to help improve treatment for patients with this serious lung condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $478,740 |
| NIH project number | 5R01HL168128-02 |
| Project ID | NIH-11001576 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with acute respiratory distress syndrome (ARDS).
✕Less likely to help
Patients with chronic respiratory conditions or those not diagnosed with ARDS may not benefit from this research.
What this research studies
This research focuses on understanding the role of a specific enzyme, NUDT21, in the development of acute respiratory distress syndrome (ARDS), a serious lung condition. The study aims to explore how NUDT21 influences the regulation of RNA, which may affect inflammation and lung injury. By examining both human and animal models, researchers will investigate how changes in NUDT21 levels impact lung inflammation and the overall severity of ARDS. The goal is to identify new therapeutic strategies that could potentially improve outcomes for patients suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that reduce lung inflammation and improve recovery for patients with ARDS.
How similar studies have gone: Previous studies have shown that targeting RNA regulation mechanisms can lead to significant improvements in inflammatory diseases, suggesting potential success for this approach.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Mills, Tingting Weng — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Mills, Tingting Weng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.