Investigating how a specific enzyme affects bladder function and dysfunction
Role of Ectonucleotidase in Voiding Function and Dysfunction
['FUNDING_R01'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10838499
This study is looking at how certain molecules affect bladder function in people with lower urinary tract symptoms, with the goal of finding new ways to help improve bladder health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10838499 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of ectonucleotidase in bladder function, particularly in patients experiencing lower urinary tract symptoms (LUTS). The study examines how purinergic signaling, which involves the action of certain molecules like ATP and adenosine, influences bladder contractions and relaxations. By identifying key receptors and enzymes involved in this signaling pathway, the research aims to uncover mechanisms that could lead to new treatments for bladder dysfunction. Patients may be involved in comparative studies to assess the differences in bladder function between humans and animal models.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing lower urinary tract symptoms, particularly those with bladder dysfunction.
Not a fit: Patients without any bladder dysfunction or those not experiencing lower urinary tract symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients suffering from bladder dysfunction and improve their quality of life.
How similar studies have performed: Previous research has shown promise in understanding purinergic signaling in bladder function, indicating that this approach could lead to meaningful advancements in treatment.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YU, WEIQUN — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: YU, WEIQUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases