Investigating how a specific chloride channel affects bacterial pneumonia and sepsis

Who could benefit from this research

What this research studies

This research focuses on understanding the role of a newly discovered chloride channel, PACC1, in the immune response to bacterial infections, particularly pneumonia and sepsis. The study examines how this channel influences the function of immune cells, specifically alveolar macrophages, which are crucial for fighting off bacterial threats. By using genetically modified mice that lack PACC1, researchers aim to uncover its importance in the acidification of phagolysosomes, a key process in destroying bacteria. The findings could lead to new insights into potential therapeutic targets for treating bacterial infections.

Why it matters

Where this research is happening

• Boston University Medical Campus
  Boston, United States Active

Researchers

• Principal investigator: Garo, Lucien Peter — Boston University Medical Campus
• Study coordinator: Garo, Lucien Peter

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.