Investigating how a specific bacterial secretion system works in a periodontal pathogen.
Structure and Function of Porphyromonas gingivalis Type IX Secretion System
['FUNDING_R01'] · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · NIH-11013294
This study is looking at a part of a germ called Porphyromonas gingivalis that is linked to gum disease, using special imaging tools to see how it works inside the germ, which could help us find new ways to treat infections related to this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11013294 on ClinicalTrials.gov |
What this research studies
This research focuses on the Type IX secretion system (T9SS) of Porphyromonas gingivalis, a bacterium linked to chronic periodontitis. By utilizing advanced imaging techniques like cryo-electron tomography, the researchers aim to visualize the T9SS in its natural environment within the bacterial cell. This approach allows for a better understanding of how this secretion system operates and how it contributes to the bacterium's ability to cause disease. The findings could lead to new insights into bacterial infections and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic periodontitis or related bacterial infections.
Not a fit: Patients with non-bacterial related periodontal issues or those not affected by chronic periodontitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for periodontal disease and other bacterial infections.
How similar studies have performed: Previous research has shown success in understanding bacterial secretion systems using advanced imaging techniques, suggesting this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HU, BO — UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
- Study coordinator: HU, BO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacteria infection, bacterial disease, Bacterial Infections