Investigating how a protein called epsin affects heart disease and blood vessel health
The role of signaling adaptor protein epsin in atherosclerosis
This study is looking at how a protein called epsin affects the development of atherosclerosis, which can lead to heart problems, and aims to find new ways to treat this condition by understanding how epsin influences inflammation and fat buildup in blood vessels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10739794 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of epsin, a signaling adaptor protein, in the development of atherosclerosis, a condition that leads to serious cardiovascular diseases. The study aims to uncover the molecular mechanisms that contribute to arterial inflammation and dyslipidemia, which are significant risk factors for heart disease. By examining how epsins influence these processes in endothelial cells and macrophages, researchers hope to identify new therapeutic targets that could lead to more effective treatments for atherosclerosis. The approach includes both laboratory studies and analysis of human atherosclerotic lesions to gather comprehensive data on epsin's role in disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerosis or related cardiovascular conditions.
Not a fit: Patients with non-cardiovascular diseases or those not affected by atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of innovative therapies that more effectively manage or prevent atherosclerosis and its associated cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in targeting molecular mechanisms related to atherosclerosis, suggesting that this approach could yield significant advancements.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Chen, Hong — Boston Children's Hospital
- Study coordinator: Chen, Hong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.