Investigating how a protein affects lung injury and inflammation
HDAC9 nuclear/cytoplasmic shuttling in pulmonary vascular endothelial barrier regulation
This study is looking at a protein called HDAC9 to see how it affects lung health during acute lung injury, especially when bacteria are involved, and it aims to find new ways to help improve lung function for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11061386 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific protein, HDAC9, in the regulation of the lung's vascular barrier during acute lung injury (ALI). It examines how this protein is affected by bacterial toxins and how its movement within cells can influence lung function. By studying both the overexpression and deletion of HDAC9 in animal models, researchers aim to uncover the molecular mechanisms that contribute to lung injury and identify potential therapeutic targets. The approach includes analyzing the protein's phosphorylation and its effects on lung endothelial cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing acute lung injury, particularly those with sepsis or related conditions.
Not a fit: Patients with chronic lung conditions or those not experiencing acute lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function and reduce mortality in patients suffering from acute lung injury.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar proteins in lung injury, suggesting that this approach may yield valuable insights.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Verin, Alexander D — Augusta University
- Study coordinator: Verin, Alexander D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.