Investigating how a protein affects lung immune cells and inflammation
The NF-kappaB modulator PDLIM2 as an intrinsic checkpoint of alveolar macrophages critical for lung innate immunity, inflammation and diseases
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11030038
This study is looking at how certain immune cells in your lungs help fight pneumonia and other lung diseases, while also exploring how they might play a role in lung cancer, focusing on a protein called PDLIM2 that affects how these cells work.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11030038 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of alveolar macrophages, which are crucial immune cells in the lungs, in the context of pneumonia and lung diseases. The study aims to explore how these cells can both protect against infections and contribute to lung cancer progression. Researchers will investigate the function of a specific protein, PDLIM2, which influences the behavior of these immune cells and their ability to manage inflammation. By examining the interactions between PDLIM2 and other immune factors, the research seeks to uncover new insights into lung immunity and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults suffering from pneumonia, lung cancer, or other lung diseases.
Not a fit: Patients with non-respiratory conditions or those without lung-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung immunity and reduce the severity of pneumonia and other lung diseases.
How similar studies have performed: Previous research has shown promising results in targeting immune checkpoints in other diseases, suggesting potential for success in this novel approach.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QU, ZHAOXIA — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: QU, ZHAOXIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome