Investigating how a protein affects inflammatory signaling in autoimmune diseases
Official title: Determining role of 14-3-3zeta in IL-17A signaling
Funded at University of Kentucky · NIH-11328229 · Data updated 2026-11-12
This study is looking at a protein called 14-3-3zeta to see how it affects a signaling process related to IL-17A, which plays a role in autoimmune diseases like Inflammatory Arthritis, with the hope of finding new ways to help people with these conditions feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | June 10, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $795,696 |
| NIH project number | 7R01AI184880-02 |
| Project ID | NIH-11328229 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autoimmune diseases, particularly those experiencing symptoms of Inflammatory Arthritis.
✕Less likely to help
Patients with non-autoimmune conditions or those who do not have inflammatory arthritis may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called 14-3-3zeta in the signaling pathway of Interleukin-17A (IL-17A), which is known to contribute to autoimmune diseases like Inflammatory Arthritis. By studying how this protein interacts with other signaling molecules, the research aims to uncover mechanisms that could lead to new treatment strategies. The approach involves using animal models to observe the effects of manipulating this protein on disease progression and inflammation. The ultimate goal is to provide insights that could help in developing therapies for patients suffering from autoimmune conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases, potentially improving the quality of life for affected patients.
How similar studies have gone: Previous research has shown promising results in understanding similar signaling pathways in autoimmune diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Chakravarti, Ritu — University of Kentucky
- Study coordinator: Chakravarti, Ritu
Related research
Other NIH-funded projects on the same topics.
-
East Palestine health impact study following train derailment
A community-engaged study in East Palestine will follow residents to understand health symptoms, exposure markers, and air quality after a major train derailment.
-
Grade C Periodontitis in Young People: Genetic Clues to a Severe, Early Condition
A research team is studying why some young people develop a severe form of gum disease called Grade C periodontitis and how genetics and bacteria like Aa may contribute.
-
Regulation of exon junction complex in cancer biology
This grant studies how a key molecular complex that controls RNA processing acts in cancer, with the aim of understanding how it contributes to cancer cell behavior.
-
Alcohol use and suicidal thoughts: how decision-making affects risk
This project looks at how acute alcohol use and people’s decision-making patterns relate to suicidal thoughts and behaviors in adults.
-
Kentucky workplace health surveillance program improving safety for workers
A national institute-funded program is supporting Kentucky to monitor and improve safety and health at work for better protection of workers.
-
Gabapentin use in older adults and related health outcomes
This project will look at how gabapentin is used by older adults and whether that use is linked to health outcomes using Medicare data.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.