Investigating how a protein affects immune cells in lung diseases
Chitinase 3-like-1 regulates neutrophil cell fate in inflammatory lung disease
['FUNDING_CAREER'] · YALE UNIVERSITY · NIH-10872999
This study is looking at how a protein called Chi3L1 affects immune cells in the lungs, which could help us find new treatments for people with asthma and chronic lung diseases.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10872999 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of chitinase 3-like-1 (Chi3L1) in regulating neutrophils, which are immune cells involved in lung diseases such as asthma and chronic obstructive pulmonary disease. The researchers will explore how Chi3L1 influences neutrophil behavior, including its effects on cell death and inflammation. By studying both animal models and patient samples, the research aims to uncover new therapeutic targets for treating these conditions. The ultimate goal is to develop neutrophil-specific therapies that could improve outcomes for patients with inflammatory lung diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from asthma, pneumonia, or chronic obstructive pulmonary disease (COPD).
Not a fit: Patients with lung diseases not primarily driven by neutrophilic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments specifically targeting neutrophil-related inflammation in lung diseases.
How similar studies have performed: Previous research has shown promise in targeting immune cell behavior for therapeutic purposes, suggesting potential success for this approach.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAUTAM, SAMIR — YALE UNIVERSITY
- Study coordinator: GAUTAM, SAMIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome