Investigating how a protein affects blood vessel barrier function in lung injuries
Official title: Molecular mechanisms relating Poldip2 to endothelial permeability
Funded at Emory University · NIH-11052470 · Data updated 2026-11-12
This study is looking at a protein called Poldip2 to see how it helps keep blood vessels in the lungs strong and healthy, which is important for preventing serious breathing problems like acute respiratory distress syndrome, and the researchers hope their findings will lead to new treatments for lung diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $690,886 |
| NIH project number | 5R01HL169373-02 |
| Project ID | NIH-11052470 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from acute respiratory distress syndrome or related lung injuries.
✕Less likely to help
Patients with chronic lung conditions unrelated to endothelial barrier dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called Poldip2 in maintaining the barrier function of blood vessels, particularly in the lungs. When this barrier is compromised, conditions like acute respiratory distress syndrome can occur, leading to severe health complications. The researchers will use animal models to explore how the absence of Poldip2 affects lung injury and permeability, aiming to uncover the molecular mechanisms involved. By identifying how Poldip2 can be targeted, the study seeks to pave the way for new therapeutic strategies to improve patient outcomes in lung-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung function and reduce mortality in patients with acute respiratory distress syndrome.
How similar studies have gone: Previous research has shown promising results in targeting similar molecular pathways to improve outcomes in lung injury models, suggesting a potential for success in this approach.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Griendling, Kathy K — Emory University
- Study coordinator: Griendling, Kathy K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.