Investigating how a key enzyme affects inflammation and metabolism in immune cells.
Official title: Acetyl CoA Carboxylase in the Metabolic Control of Inflammation
Funded at University of Virginia · NIH-10897206 · Data updated 2026-11-12
This study is looking at how a specific protein called ACC affects inflammation and metabolism in immune cells, especially in people with obesity and diabetes, to find ways to help their bodies fight infections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $621,038 |
| NIH project number | 5R01AI168194-02 |
| Project ID | NIH-10897206 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with preexisting conditions such as obesity and diabetes who are at risk for inadequate immune responses.
✕Less likely to help
Patients without metabolic disorders or those not experiencing inflammatory responses may not benefit from this research.
What this research studies
This research focuses on understanding the role of Acetyl CoA Carboxylase (ACC) in regulating inflammation and metabolism within immune cells, particularly macrophages. The study aims to explore how metabolic changes in these cells influence their ability to respond to infections, especially in patients with conditions like obesity and diabetes. By examining the metabolic pathways activated during inflammation, researchers hope to uncover new insights into how to improve immune responses and resolve infections more effectively.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response in patients with metabolic disorders, improving their ability to fight infections.
How similar studies have gone: Previous research has shown promising results in understanding metabolic regulation in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Leitinger, Norbert — University of Virginia
- Study coordinator: Leitinger, Norbert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.