Investigating how a gene related to Down Syndrome affects development and health.
DYRK1A interaction network in development and disease
This study is looking at a gene called DYRK1A, which is important for children with Down Syndrome, to see if changing how it works during early development can help improve their health and reduce birth defects.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-10373183 on NIH RePORTER |
What this research studies
This research focuses on the DYRK1A gene, which is linked to Down Syndrome and its associated birth defects. The team aims to explore how modulating the function of DYRK1A during embryonic development can improve outcomes for children with Down Syndrome. They will use biochemical assays in human cells and studies in the Xenopus laevis model to understand the role of two newly identified proteins that interact with DYRK1A. The goal is to develop precise methods to manipulate DYRK1A without harmful side effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are unborn children diagnosed with Down Syndrome or those at risk due to genetic factors.
Not a fit: Patients who are not affected by Down Syndrome or related genetic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved developmental outcomes for children with Down Syndrome.
How similar studies have performed: While the approach of modulating DYRK1A is innovative, similar research has shown promise in understanding gene interactions in developmental processes.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Litovchick, Larisa — Virginia Commonwealth University
- Study coordinator: Litovchick, Larisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.