Investigating how a different method of protein production affects advanced breast cancer metabolism
Official title: The role of an alternate mechanism of translation initiation in TNBC Metabolism
Funded at Herbert H. Lehman College · NIH-11093387 · Data updated 2026-11-12
This study is looking at how advanced Triple Negative Breast Cancer changes the way it uses energy to survive tough conditions, like low oxygen or lack of nutrients, and hopes to find new ways to help patients by understanding how their cancer works better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Herbert H. Lehman College NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $138,072 |
| NIH project number | 5R16GM153947-02 |
| Project ID | NIH-11093387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with advanced Triple Negative Breast Cancer.
✕Less likely to help
Patients with non-advanced breast cancer or other types of cancer may not receive benefit from this research.
What this research studies
This research focuses on understanding how advanced breast cancer, particularly Triple Negative Breast Cancer (TNBC), alters its metabolism to survive and spread. It aims to explore a unique mechanism of protein synthesis that cancer cells use when faced with stress, such as low oxygen or nutrient deprivation. By identifying which specific mRNAs are translated during these stressful conditions, the study hopes to uncover new insights into the aggressive nature of TNBC and its resistance to treatments. Patients may benefit from a better understanding of how their cancer behaves and potentially lead to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatment approaches that target the metabolic adaptations of TNBC, improving patient outcomes.
How similar studies have gone: While the specific approach of investigating non-canonical translation mechanisms in TNBC is relatively novel, similar research has shown promise in understanding cancer metabolism and treatment resistance.
Where this research is happening
-
Herbert H. Lehman College
New York, United States Active
Researchers
- Principal investigator: De la Parra, Columba — Herbert H. Lehman College
- Study coordinator: De la Parra, Columba
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.